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F11062P01

Anti-Human CD62P, FITC (Clone:AK-4) (新品)

¥1,584.00

  • 分子靶点：SELP, CD62P, GRMP
  • 种属：人 (Human)
  • 标记：FITC
  • 亚型：Mouse IgG1, κ
  • 克隆号：AK-4

在售SKU, 70-AH062P01-20, 70-AH062P01-50, 70-AH062P01-100, AH062P01, 70-F11062P01-25, 70-F11062P01-100


 100T

F11062P01-100
-+

描述

商品名

Anti-Human CD62P, FITC (Clone:AK-4)
靶点

SELP, CD62P, GRMP
标记

FITC
仪器

适用488nm激光器的流式细胞仪
亚型

Mouse IgG1, κ
克隆号

AK-4
推荐应用

流式检测
用量

5 μL /Test
纯化

亲和层析
储存液

含 0.2% BSA 和 0.2% proclin 950 的磷酸盐缓冲液(pH7.2)
保存条件

2 - 8℃避光，切勿冻存

结果示例

Anti-Human CD62P, FITC (Clone:AK-4) - 结果示例图片
结果示例

图 - 人外周血染色 Anti-Human CD62P, FITC (F11062P01)(实线) 和 Mouse IgG1 κ Isotype Control FITC(CMG101) (虚线)的结果。以血小板设门进行分析。

分子信息

概述人 SELP, CD62P, GRMP 靶点信息

SELP 分子靶点信息概述

  • 分子名：SELP, selectin P
  • 基因家族：CD molecules; Selectins; Sushi domain containing; C-type lectin domain containing
  • 别名：CD62; PSEL; PADGEM; GMP140; CD62P
  • 曾用名：GRMP
  • 全称：antigen CD62; granule membrane protein 140kDa; selectin P (granule membrane protein 140kD, antigen CD62); selectin P (granule membrane protein 140kDa, antigen CD62)

SELP 分子靶点综述

CD62P 是一种 140kDa 跨膜糖蛋白，也称为 P-Selectin。P-Selectin被储存在血小板的 α 颗粒和内皮细胞的 Weibel-Palade 小体中，并在激活后迅速转运到质膜。在炎症反应中，P-Selectin 被认为介导中性粒细胞和单核细胞与内皮的初始粘附相互作用；在止血过程中，活化的血小板与中性粒细胞和单核细胞相互作用。

人 Human SELP 分子靶点信息

  • 分子名：SELP, selectin P
  • 别称：
    • CD62
    • CD62 antigen-like family member P
    • CD62P
    • FLJ45155
    • GMP-140
    • GMP140
    • granule membrane protein 140
    • granule membrane protein 140kDa
    • granulocyte membrane protein
    • GRMP
    • LECAM3
    • leukocyte-endothelial cell adhesion molecule 3
    • P-selectin
    • PADGEM
    • platelet activation dependent granule-external membrane protein
    • platelet alpha-granule membrane protein
    • PSEL
    • selectin P (granule membrane protein 140kDa, antigen CD62)
  • 基因序列：NCBI_Gene: 6403
  • 蛋白序列：UniProtKB: P16109

人 Human SELP靶点分子功能（预测）

Enables several functions, including fucose binding activity; heparin binding activity; and lipopolysaccharide binding activity. Involved in several processes, including calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules; calcium-mediated signaling using intracellular calcium source; and leukocyte tethering or rolling. Located in external side of plasma membrane; extracellular space; and platelet alpha granule membrane. Is integral component of plasma membrane. Implicated in atopic dermatitis and myocardial infarction. Biomarker of several diseases, including Kawasaki disease; autoimmune disease (multiple); coronary artery disease (multiple); obesity; and type 2 diabetes mellitus.

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